Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro

Indian J Pharmacol. 2014 Jul-Aug;46(4):430-2. doi: 10.4103/0253-7613.135958.

Abstract

Objectives: To investigate the antiplatelet activity of alpha-lipoic acid (α-LA) and dihydroquercetin (DHQ).

Methods: Antiplatelet activity of the α-LA and DHQ was evaluated in rich platelet plasma of rat. The platelet aggregation was induced by adenosine diphosphate (ADP) in concentration of 4 × 10(-5) M.

Results: α-LA and DHQ inhibited platelet aggregation in concentration-dependent manner. The antiplatelet activity of α-LA was more pronounced than DHQ. DHQ also increased the antiplatelet activity of α-LA by 1.4 times.

Conclusion: Combined simultaneous use of α-LA and DHQ possessed the high antiplatelet activity, and DHQ potentiated the activity of α-LA.

Keywords: Alpha-lipoic acid; antioxidants; antiplatelet activity; dihydroquercetin; platelet aggregation.

MeSH terms

  • Adenosine Diphosphate / pharmacology*
  • Animals
  • Blood Platelets / cytology
  • Blood Platelets / drug effects
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Male
  • Platelet Aggregation / drug effects*
  • Platelet Aggregation Inhibitors / pharmacology*
  • Platelet-Rich Plasma
  • Quercetin / analogs & derivatives*
  • Quercetin / pharmacology
  • Rats, Wistar
  • Thioctic Acid / pharmacology*

Substances

  • Platelet Aggregation Inhibitors
  • Adenosine Diphosphate
  • Thioctic Acid
  • Quercetin
  • taxifolin