A one-pot synthetic strategy for construction of the dibenzodiazepine skeleton via a transition metal-free process

Org Biomol Chem. 2014 Sep 21;12(35):6895-900. doi: 10.1039/c4ob00871e.

Abstract

A one-pot transition metal-free methodology for constructing pharmacologically active dibenzodiazepine derivatives was developed. Fluoro-, bromo- and nitro-substituted aryl aldehydes were applied to this reaction efficiently.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry
  • Benzodiazepines / chemical synthesis*
  • Benzodiazepines / chemistry
  • Catalysis
  • Chemistry, Organic / methods*
  • Chemistry, Pharmaceutical / methods*
  • Drug Design
  • Metals / chemistry
  • Molecular Structure
  • Pharmaceutical Preparations / chemistry
  • Temperature
  • Transition Elements

Substances

  • Aldehydes
  • Metals
  • Pharmaceutical Preparations
  • Transition Elements
  • Benzodiazepines