Is there a binding deficit in working memory in patients with schizophrenia? A meta-analysis

Stéphanie Grot; Stéphane Potvin; David Luck

doi:10.1016/j.schres.2014.06.012

Is there a binding deficit in working memory in patients with schizophrenia? A meta-analysis

Schizophr Res. 2014 Sep;158(1-3):142-5. doi: 10.1016/j.schres.2014.06.012. Epub 2014 Jul 19.

Authors

Stéphanie Grot¹, Stéphane Potvin¹, David Luck²

Affiliations

¹ Centre de recherche, Institut universitaire en santé mentale de Montréal, Montreal, Quebec, Canada; Department of Psychiatry, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
² Centre de recherche, Institut universitaire en santé mentale de Montréal, Montreal, Quebec, Canada; Department of Psychiatry, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada. Electronic address: david.luck@umontreal.ca.

PMID: 25048424
DOI: 10.1016/j.schres.2014.06.012

Abstract

In schizophrenia (SZ), a specific binding deficit in working memory (WM) has not yet been demonstrated, given that studies with various methodologies were conducted and the results obtained were heterogeneous. Thus, a meta-analysis of 10 WM studies was performed. Effect sizes were calculated for binding and control conditions. Analyses disclosed significantly lower scores in SZ patients relative to controls for both binding and control conditions. In addition, analyses revealed no greater impairments for the binding condition than for the control condition in SZ patients. Our meta-analysis suggests that there is no specific deficit of binding in WM in SZ.

Keywords: Binding; Meta-analysis; Schizophrenia; Working memory.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Association Learning
Humans
Memory, Short-Term*
Regression Analysis
Schizophrenic Psychology*