Histopathological screening for prostate carcinoma: is a benign biopsy a negative biopsy?

APMIS. 2014 Aug;122(8):690-8. doi: 10.1111/apm.12291.

Abstract

In case of clinical suspicion of a prostate malignancy, a prostate biopsy is the most widely used approach to confirm prostate cancer. Unfortunately, exclusion of prostate cancer is not feasible by means of biopsy and also the negative rate remains consistently high. Here, we review the information the surgical pathologist can still gain from a prostate biopsy in absence of overt carcinoma.

Keywords: ASAP; PIA; PIN; Prostate; biopsy.

Publication types

  • Review

MeSH terms

  • Biopsy
  • Carcinoma, Intraductal, Noninfiltrating / pathology
  • Digital Rectal Examination
  • Early Detection of Cancer
  • Glutathione S-Transferase pi / metabolism
  • Humans
  • Male
  • Prostate / pathology*
  • Prostate / surgery*
  • Prostate-Specific Antigen / blood
  • Prostatic Intraepithelial Neoplasia / pathology
  • Prostatic Neoplasms / pathology*

Substances

  • GSTP1 protein, human
  • Glutathione S-Transferase pi
  • Prostate-Specific Antigen