Noncoding RNAs in the regulation of DNA replication

Xin Quan Ge; Haifan Lin

doi:10.1016/j.tibs.2014.06.003

Noncoding RNAs in the regulation of DNA replication

Trends Biochem Sci. 2014 Aug;39(8):341-3. doi: 10.1016/j.tibs.2014.06.003. Epub 2014 Jul 12.

Authors

Xin Quan Ge¹, Haifan Lin²

Affiliations

¹ Yale Stem Cell Center and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA.
² Yale Stem Cell Center and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: haifan.lin@yale.edu.

Abstract

Noncoding RNAs (ncRNAs) have crucial roles in epigenetic, transcriptional, and post-transcriptional regulation. Recent studies have begun to reveal a role of ncRNAs in DNA replication. Here, we review the roles of ncRNAs in regulating different aspects of DNA replication in prokaryotic and eukaryotic systems. We speculate that ncRNAs might function to guide the origin recognition complex (ORC) to chromosomal DNA during replication initiation in higher eukaryotes.

Keywords: DNA replication; ORC; miRNA; noncoding RNA; primer.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
DNA Replication*
Gene Expression Regulation*
Humans
RNA, Untranslated / genetics*
Transcription, Genetic*

Substances

RNA, Untranslated

Abstract

Publication types

MeSH terms

Substances

Grants and funding