Abstract
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Increasing evidence suggests that microRNAs (miRNAs) are associated with HCC tumorigenesis. The present study was designed to define the role of miR-141 in HCC. The expression of miR-141 was significantly decreased in four HCC cell lines. Overexpression of miR-141 suppressed both the growth and the motility of HCC cells. Furthermore, we identified zinc finger E-box binding homeobox 2 (ZEB2) as a target of miR-141 and miR-141 functioned as a tumor suppressor via ZEB2 targeting in HCC. These data provide a novel potential therapeutic target for HCC treatment.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Blotting, Western
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Carcinoma, Hepatocellular / genetics
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Carcinoma, Hepatocellular / metabolism
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Carcinoma, Hepatocellular / pathology*
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Cell Line, Tumor
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Disease Progression
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Gene Expression Regulation, Neoplastic / physiology*
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Genes, Tumor Suppressor
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Homeodomain Proteins / biosynthesis*
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Homeodomain Proteins / genetics
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Humans
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Liver Neoplasms / genetics
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Liver Neoplasms / metabolism
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Liver Neoplasms / pathology*
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MicroRNAs / genetics
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MicroRNAs / metabolism
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Repressor Proteins / biosynthesis*
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Repressor Proteins / genetics
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Reverse Transcriptase Polymerase Chain Reaction
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Zinc Finger E-box Binding Homeobox 2
Substances
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Homeodomain Proteins
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MIRN141 microRNA, human
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MicroRNAs
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Repressor Proteins
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ZEB2 protein, human
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Zinc Finger E-box Binding Homeobox 2