Anxiety disorders are associated with quality of life impairment in patients with insulin-dependent type 2 diabetes: a case-control study

Braz J Psychiatry. 2014 Oct-Dec;36(4):298-304. doi: 10.1590/1516-4446-2013-1230. Epub 2014 Jun 24.

Abstract

Objective: To assess the presence of anxiety disorders and quality of life in patients with insulin-dependent type 2 diabetes.

Methods: Case-control study of 996 patients with type 2 diabetes and 2,145 individuals without diabetes. The sole inclusion criterion for the case group was insulin-dependent type 2 diabetes. We compared the case and control groups for sociodemographic variables, laboratory and clinical data, and presence of anxiety disorders. Quality of life was evaluated using the WHOQOL-BREF instrument, and the prevalence of anxiety disorder was evaluated by the Mini International Neuropsychiatric Interview (MINI).

Results: Patients with diabetes had a higher prevalence of generalized anxiety disorder, panic disorder, and obsessive-compulsive disorder. The presence of these disorders in combination with type 2 diabetes was associated with worse quality of life in the physical, social, psychological, and environmental domains.

Conclusions: This study demonstrates the importance of diagnosing and treating anxiety disorders in patients with diabetes, so as to prevent more serious complications associated with these comorbidities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anxiety Disorders / physiopathology
  • Anxiety Disorders / psychology*
  • Case-Control Studies
  • Diabetes Mellitus, Type 1 / physiopathology
  • Diabetes Mellitus, Type 1 / psychology*
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / physiopathology
  • Female
  • Humans
  • Hypoglycemic Agents / therapeutic use*
  • Insulin / therapeutic use
  • Male
  • Marital Status
  • Multivariate Analysis
  • Quality of Life / psychology*
  • Social Environment
  • Socioeconomic Factors
  • Surveys and Questionnaires

Substances

  • Hypoglycemic Agents
  • Insulin

Supplementary concepts

  • Diabetes Mellitus, Insulin-Dependent, 2