Phosphines are an important class of ligands in the field of metal-catalysis. This has spurred the development of new routes toward functionalized phosphines. Some of the most important C-P bond formation strategies were reviewed and organized according to the hybridization of carbon in the newly formed C-P bond.
Keywords: cross-coupling; enantioselectivity; hydrophosphination; organophosphorus chemistry; phosphine-boranes; phosphines; substitution reactions; trivalent phosphorus.