Variants identified by hepatocellular carcinoma and chronic hepatitis B virus infection susceptibility GWAS associated with survival in HBV-related hepatocellular carcinoma

Cong Li; Xinyu Bi; Ying Huang; Jianjun Zhao; Zhiyu Li; Jianguo Zhou; Meng Zhang; Zhen Huang; Hong Zhao; Jianqiang Cai

doi:10.1371/journal.pone.0101586

Variants identified by hepatocellular carcinoma and chronic hepatitis B virus infection susceptibility GWAS associated with survival in HBV-related hepatocellular carcinoma

PLoS One. 2014 Jul 2;9(7):e101586. doi: 10.1371/journal.pone.0101586. eCollection 2014.

Authors

Cong Li¹, Xinyu Bi¹, Ying Huang², Jianjun Zhao¹, Zhiyu Li¹, Jianguo Zhou¹, Meng Zhang², Zhen Huang¹, Hong Zhao¹, Jianqiang Cai¹

Affiliations

¹ Department of Abdominal Surgical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
² Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Abstract

Recent genome-wide association studies (GWAS) have identified several common susceptibility loci associated with the risk of hepatocellular carcinoma (HCC) or chronic hepatitis B infection (CHB). However, the relationship between these genetic variants and survival of patients with hepatitis B virus (HBV)-related HCC is still unknown. In this study, 22 single nucleotide polymorphisms (SNPs) were genotyped among 330 HBV-related HCC patients using the MassARRAY system from Sequenom. Cox proportional hazards regression was used to examine the effects of genotype on survival time under an additive model with age, sex, smoking status and clinical stage as covariates. We identified four SNPs on 6p21 (rs1419881 T>C, rs7453920 G>A,rs3997872 G>A and rs7768538 T>C), and two SNPs on 8p12 (rs2275959 C>T and rs7821974 C>T) significantly associated with survival time of HBV-related HCC patients. Our results suggest that HCC or CHB susceptibility loci might also affect the prognosis of patients with HBV-related HCC.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Carcinoma, Hepatocellular / complications
Carcinoma, Hepatocellular / epidemiology
Carcinoma, Hepatocellular / genetics*
Carcinoma, Hepatocellular / virology*
Female
Genome-Wide Association Study*
Hepatitis B virus / isolation & purification
Hepatitis B, Chronic / complications
Hepatitis B, Chronic / epidemiology
Hepatitis B, Chronic / genetics*
Humans
Liver Neoplasms / complications
Liver Neoplasms / epidemiology
Liver Neoplasms / genetics*
Liver Neoplasms / virology*
Male
Middle Aged
Polymorphism, Single Nucleotide*
Survival Analysis

Grants and funding

This study was supported by grants from the National Natural Science Foundation of China (81201967), the Beijing Natural Science Foundation (7132193), Beijing Nova Program (No. 2009A69), and the State Key Project on Infectious Diseases of China (China National Science and Technology Major Project Grant during the Twelfth Five-year Plan Period No.2012ZX10002-016). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.