Retrograde flow of cadherins in collective cell migration

Nat Cell Biol. 2014 Jul;16(7):621-3. doi: 10.1038/ncb2995.

Abstract

Collective cell migration is characterized by the maintenance of intercellular contacts during cell movement. The maintenance of N-cadherin-based junctions during collective migration is now shown to be facilitated by their treadmilling from the cell front to the rear, followed by N-cadherin endocytosis and recycling to the leading edge.

Publication types

  • Comment

MeSH terms

  • Adherens Junctions / metabolism*
  • Animals
  • Cell Movement*