Overview and comparison of ortholog databases

Andrey Alexeyenko; Julia Lindberg; Asa Pérez-Bercoff; Erik L L Sonnhammer

doi:10.1016/j.ddtec.2006.06.002

Overview and comparison of ortholog databases

Drug Discov Today Technol. 2006 Summer;3(2):137-43. doi: 10.1016/j.ddtec.2006.06.002.

Authors

Andrey Alexeyenko¹, Julia Lindberg¹, Asa Pérez-Bercoff¹, Erik L L Sonnhammer²

Affiliations

¹ Stockholm Bioinformatics Center, Albanova, Stockholm University, SE-106 91, Stockholm, Sweden.
² Stockholm Bioinformatics Center, Albanova, Stockholm University, SE-106 91, Stockholm, Sweden. Electronic address:Erik.Sonnhammer@sbc.su.se.

PMID: 24980400
DOI: 10.1016/j.ddtec.2006.06.002

Abstract

Orthologs are an indispensable bridge to transfer biological knowledge between species, from protein annotations to sophisticated disease models. However, orthology assignment is not trivial. A large number of resources now exist, each with its own idiosyncrasies. The goal of this review is to compare their contents and clarify which database is most suited for a certain task.: