Design, synthesis and biological evaluation of mitochondria targeting theranostic agents

Chem Commun (Camb). 2014 Aug 18;50(64):8919-22. doi: 10.1039/c4cc03296a.

Abstract

Dual mitochondria targeting fluorescent F16-TPP analogues were designed and synthesized. Uptake and cytotoxicity studies indicate that FF16 and FF16-TPP, two compounds discovered in this study, are promising mitochondria targeting theranostic agents.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antineoplastic Agents* / chemical synthesis
  • Antineoplastic Agents* / pharmacology
  • Antineoplastic Agents* / therapeutic use
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Drug Design
  • Humans
  • Indoles* / chemical synthesis
  • Indoles* / pharmacology
  • Indoles* / therapeutic use
  • Mitochondria / metabolism*
  • Onium Compounds* / chemical synthesis
  • Onium Compounds* / pharmacology
  • Onium Compounds* / therapeutic use
  • Optical Imaging
  • Organophosphorus Compounds* / chemical synthesis
  • Organophosphorus Compounds* / pharmacology
  • Organophosphorus Compounds* / therapeutic use
  • Pyridinium Compounds* / chemical synthesis
  • Pyridinium Compounds* / pharmacology
  • Pyridinium Compounds* / therapeutic use

Substances

  • Antineoplastic Agents
  • Indoles
  • Onium Compounds
  • Organophosphorus Compounds
  • Pyridinium Compounds
  • 4-(2-(indol-3-yl)vinyl)-1-methylpyridinium
  • tetraphenylphosphonium