Causes and pathophysiology of heart failure with preserved ejection fraction

Heart Fail Clin. 2014 Jul;10(3):389-98. doi: 10.1016/j.hfc.2014.04.002. Epub 2014 May 22.

Abstract

Heart failure with preserved ejection fraction (HFPEF) is frequently associated with multiple disorders complicating both the clinical management and the understanding of the underlying mechanisms. This review focuses on the causes and pathophysiology of HFPEF and overviews how cellular and molecular changes related to various comorbidities may influence the age-dependent and gender-dependent hemodynamic alterations of diastolic ventricular function.

Keywords: Comorbidities; Exercise intolerance; Heart failure with preserved ejection fraction; Myocardial stiffness; Ventricular-arterial uncoupling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Age Distribution
  • Aged
  • Aortic Valve Stenosis / diagnosis
  • Aortic Valve Stenosis / epidemiology
  • Comorbidity
  • Diabetes Mellitus / epidemiology
  • Diabetes Mellitus / physiopathology
  • Female
  • Heart Failure / epidemiology*
  • Heart Failure / physiopathology*
  • Heart Failure, Diastolic / epidemiology
  • Heart Failure, Diastolic / physiopathology
  • Heart Failure, Systolic / epidemiology
  • Heart Failure, Systolic / physiopathology
  • Humans
  • Middle Aged
  • Obesity / epidemiology
  • Obesity / physiopathology
  • Oxidative Stress / physiology
  • Prevalence
  • Prognosis
  • Risk Assessment
  • Sex Distribution
  • Stroke Volume / physiology*
  • Survival Analysis
  • Syndrome
  • Vascular Stiffness / physiology*