Drug-induced gastrointestinal disorders

Postgrad Med J. 2014 Jul;90(1065):411-9. doi: 10.1136/postgradmedj-2013-100316rep.

Abstract

Drug-induced gastrointestinal disorders can mimic conditions, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and, hence, recognition can prevent unnecessary investigations and treatment. While the knowledge and awareness relating to the adverse gastrointestinal effects of some medications, such as non-steroidal anti-inflammatory drugs are well established, other commonly prescribed drugs, such as antipsychotics, antidepressants and metformin are less well understood and warrant further study. This review attempts to integrate recent information regarding adverse drug reactions and place this in a useful clinical context.

Keywords: Adverse Drug Reactions; Clinical Decision Making; Colorectal Motility; Crohn'S Disease; Diarrhoea.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Antidepressive Agents / administration & dosage*
  • Antipsychotic Agents / adverse effects*
  • Drug Administration Schedule
  • Gastrointestinal Agents / adverse effects*
  • Gastrointestinal Diseases / chemically induced*
  • Humans
  • Inflammatory Bowel Diseases
  • Irritable Bowel Syndrome
  • Metformin / adverse effects*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antidepressive Agents
  • Antipsychotic Agents
  • Gastrointestinal Agents
  • Metformin