Abstract
We report the design and synthesis of a specific mitochondrial fluorescent probe AIE-MitoGreen-1 with AIE characteristics to monitor the mitochondrial morphology changes and identify the differentiation process of living brown adipose cells. The probe AIE-MitoGreen-1 has significant advantages such as high cellpermeability, good mitochondrial retention, low background fluorescence, large Stokes shift, and low toxicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adipose Tissue, Brown / metabolism*
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Cell Differentiation
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Cell Survival / drug effects
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Fluorescent Dyes / chemistry*
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Fluorescent Dyes / toxicity
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Humans
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Hydrazines / chemistry*
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Hydrazines / toxicity
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Microscopy, Fluorescence
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Mitochondria / pathology*
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Pyridinium Compounds / chemistry*
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Pyridinium Compounds / toxicity
Substances
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AIE-MitoGreen-1
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Fluorescent Dyes
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Hydrazines
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Pyridinium Compounds