Can the effects of protein restriction on the progression of renal failure also be achieved by pharmacological means?

Abstract

A review is given of recent data on the role of cyclo-oxygenase products in mediating glomerular hyperfiltration in renal disease and on the role of prostaglandins in protein-induced glomerular hyperfiltration. The possible beneficial effects of cyclo-oxygenase inhibitors and thromboxane synthetase inhibitors are discussed.