Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue

Org Biomol Chem. 2014 Jul 28;12(28):5235-42. doi: 10.1039/c4ob00149d.

Abstract

Herein, we report optically pure modified acyclic nucleosides as ideal probes for aptamer modification. These new monomers offer unique advantages in exploring the role played in thrombin inhibition by a single residue modification at key positions of the TBA structure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antithrombins / chemical synthesis*
  • Antithrombins / chemistry
  • Aptamers, Nucleotide / chemical synthesis*
  • Aptamers, Nucleotide / chemistry
  • Circular Dichroism
  • G-Quadruplexes
  • Models, Molecular
  • Molecular Mimicry
  • Nucleosides / chemistry*
  • Optical Rotation
  • Stereoisomerism
  • Thermodynamics
  • Thrombin / antagonists & inhibitors*
  • Thrombin / chemistry

Substances

  • Antithrombins
  • Aptamers, Nucleotide
  • Nucleosides
  • thrombin aptamer
  • Thrombin