A photothermal cell viability-reporting theranostic nanoprobe for intraoperative optical ablation and tracking of tumors

Shuqi Wu; Shoufa Han; Jiahuai Han; Xinhui Su

doi:10.1039/c4cc01823k

A photothermal cell viability-reporting theranostic nanoprobe for intraoperative optical ablation and tracking of tumors

Chem Commun (Camb). 2014 Jul 28;50(59):8014-7. doi: 10.1039/c4cc01823k.

Authors

Shuqi Wu¹, Shoufa Han, Jiahuai Han, Xinhui Su

Affiliation

¹ Department of Chemical Biology, College of Chemistry and Chemical Engineering, Key Laboratory for Chemical Biology of Fujian Province, MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Innovation Center for Cell Biology, Xiamen University, Xiamen 361005, China. shoufa@xmu.edu.cn.

PMID: 24918105
DOI: 10.1039/c4cc01823k

Abstract

A photothermal pH-reporting nanoprobe was developed for intraoperative tumor detection by "turn-on" fluorescence of the probe inside viable tumor cells, photothermal tumor therapy, and in situ monitoring of tumor killing by non-fluorescence of the probe in damaged cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Death / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects
Cell Survival
Disease Models, Animal
Female
Fluorescent Dyes / administration & dosage
Fluorescent Dyes / chemistry
Fluorescent Dyes / pharmacology*
HeLa Cells
Hep G2 Cells
Humans
Hydrogen-Ion Concentration
Mammary Neoplasms, Experimental / drug therapy*
Mammary Neoplasms, Experimental / pathology
Mice
Mice, Inbred BALB C
Molecular Structure
Nanoparticles / chemistry*
Particle Size
Photochemotherapy*
Surface Properties

Substances

Fluorescent Dyes