Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression

Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1764-9. doi: 10.1107/S1399004714007883. Epub 2014 May 30.

Abstract

The X-ray crystal structure of the Lymphocytic choriomeningitis virus nucleoprotein C-terminal immunosuppressive domain (LCMV NPΔ340) was determined to 2.0 Å resolution. The structure indicates that LCMV NPΔ340, like the other structurally characterized arenaviral nucleoproteins, adopts the fold of an exonuclease. This structure provides a crucial three-dimensional template for functional exploration of the replication and immunosuppression of this prototypic arenavirus.

Keywords: Lymphocytic choriomeningitis virus; nucleoprotein.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Immune Tolerance*
  • Lymphocytic choriomeningitis virus / metabolism*
  • Lymphocytic choriomeningitis virus / physiology
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid
  • Viral Proteins / chemistry
  • Viral Proteins / metabolism*
  • Virus Replication*

Substances

  • Viral Proteins

Associated data

  • PDB/4O6H
  • PDB/4O6I