The Authors report a case of vaginitis caused by Eikenella corrodens (E.C.) and point out it is very rare all over the world (probably the first case reported in Italy). The E.C. was the only one isolated from the vaginal specimen. They emphasized the importance of bacteria isolation in subacute or relapsing vaginitis and relevant sensibility to antibiotic assays. These are generally neglected but still able to give unexpected results then allowing a target therapy.