Getting a grip on piRNA cluster transcription

Cell. 2014 Jun 5;157(6):1253-1254. doi: 10.1016/j.cell.2014.05.022.

Abstract

The generation of piRNAs from long primary transcripts requires specialized factors that distinguish these precursors from canonical RNA polymerase II transcripts. Mohn et al. and Zhang et al. provide evidence that in Drosophila melanogaster noncanonical transcription coupled with splicing inhibition differentiates piRNA precursors from mRNAs and ensures their correct processing.

Publication types

  • Comment

MeSH terms

  • Animals
  • Chromosomal Proteins, Non-Histone / metabolism*
  • Drosophila Proteins / metabolism*
  • Drosophila melanogaster / genetics*
  • Drosophila melanogaster / metabolism*
  • Female
  • Microtubule-Associated Proteins / metabolism*
  • RNA Splicing*
  • RNA, Small Interfering / genetics*
  • RNA-Binding Proteins / metabolism*
  • Transcription, Genetic*

Substances

  • Chromosomal Proteins, Non-Histone
  • Cuff protein, Drosophila
  • Drosophila Proteins
  • Microtubule-Associated Proteins
  • RNA, Small Interfering
  • RNA-Binding Proteins
  • del protein, Drosophila
  • rhi protein, Drosophila