Abstract
Examples of organometallic compounds as nucleoside analogues are rare within the field of medicinal bioorganometallic chemistry. We report on the synthesis and properties of two chiral ferrocene derivatives containing a nucleobase and a hydroxyalkyl group. These so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five different cancer cell lines indicating that both functional groups are required for optimal activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Ferrous Compounds / chemistry*
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Ferrous Compounds / pharmacokinetics
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Humans
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Leukemia L1210 / drug therapy
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Metallocenes
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Nucleosides / chemical synthesis*
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Nucleosides / pharmacology
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Organometallic Compounds / chemical synthesis*
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Organometallic Compounds / chemistry
Substances
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Antineoplastic Agents
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Ferrous Compounds
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Metallocenes
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Nucleosides
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Organometallic Compounds
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ferrocene