Human stem cells for modeling heart disease and for drug discovery

Sci Transl Med. 2014 Jun 4;6(239):239ps6. doi: 10.1126/scitranslmed.3008921.

Abstract

A major research focus in the field of cardiovascular medicine is the prospect of using stem cells and progenitor cells for cardiac regeneration. With the advent of induced pluripotent stem cell (iPSC) technology, major efforts are also underway to use iPSCs to model heart disease, to screen for new drugs, and to test candidate drugs for cardiotoxicity. Here, we discuss recent advances in the exciting fields of stem cells and cardiovascular disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Drug Discovery*
  • Heart Diseases / therapy*
  • Humans
  • Models, Cardiovascular*
  • Stem Cell Transplantation*
  • Stem Cells / cytology*
  • Wound Healing