Chemical constituents from Eucalyptus citriodora Hook leaves and their glucose transporter 4 translocation activities

Bioorg Med Chem Lett. 2014 Jul 15;24(14):3096-9. doi: 10.1016/j.bmcl.2014.05.014. Epub 2014 May 16.

Abstract

Bioassay-guided phytochemical investigation of the EtOAc fraction from the leaves of a Chinese medicinal herb, Eucalyptus citriodora Hook, resulted in the isolation of a new compound rhodomyrtosone E (1), along with 12 known compounds (2-13). The structure of the new compound was established by 1D and 2D NMR, MS data and X-ray crystallographic analysis. Betulinic acid (2) and corosolic acid (5) increased glucose transporter 4 (GLUT-4) translocation by 2.38 and 1.78-fold, respectively.

Keywords: Antidiabetic; Eucalyptus citriodora; GLUT-4; Triketone–dihydrochalcone conjugate; Triterpenes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Chalcones / chemistry
  • Chalcones / isolation & purification
  • Chalcones / pharmacology*
  • Crystallography, X-Ray
  • Eucalyptus / chemistry*
  • Glucose Transporter Type 4 / metabolism*
  • Models, Molecular
  • Molecular Structure
  • Plant Leaves / chemistry*
  • Rats
  • Xanthenes / chemistry
  • Xanthenes / isolation & purification
  • Xanthenes / pharmacology*

Substances

  • Chalcones
  • Glucose Transporter Type 4
  • Xanthenes
  • rhodomyrtosone E