Association between COMT Val158Met genotype and EEG alpha peak frequency tested in two independent cohorts

Cornelis P M Veth; Martijn Arns; Wilhelmus Drinkenburg; Willem Talloen; Pieter J Peeters; Evian Gordon; Jan K Buitelaar

doi:10.1016/j.psychres.2014.05.021

Association between COMT Val158Met genotype and EEG alpha peak frequency tested in two independent cohorts

Psychiatry Res. 2014 Sep 30;219(1):221-4. doi: 10.1016/j.psychres.2014.05.021. Epub 2014 May 20.

Authors

Cornelis P M Veth¹, Martijn Arns², Wilhelmus Drinkenburg³, Willem Talloen³, Pieter J Peeters³, Evian Gordon⁴, Jan K Buitelaar⁵

Affiliations

¹ Radboud University Medical Center, Department of Psychiatry, PO Box 9101, 6500 HB Nijmegen, The Netherlands; Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Department of Cognitive Neuroscience, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: cpmveth@gmail.com.
² Research Institute Brainclinics, Bijleveldsingel 34, 6524 AD Nijmegen, The Netherlands; Utrecht University, Department of Experimental Psychology, Utrecht, The Netherlands.
³ Janssen Research and Development, Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, B-2340 Beerse, Belgium.
⁴ Brain Resource Limited, Level 12, 235 Jones St. Ultimo, NSW 2007, Australia.
⁵ Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Department of Cognitive Neuroscience, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

PMID: 24889847
DOI: 10.1016/j.psychres.2014.05.021

Abstract

This study could not confirm the association between the Catechol-O-Methyltransferase Val158Met polymorphism (COMT) and electroencephalographic (EEG) alpha peak frequency (APF) in two independent cohorts of 187 (96 depressed and 91 healthy participants) and 413 healthy participants. If COMT and APF play a role in depression or antidepressant treatment response, they do not have a shared pathway. We emphasize the importance of publishing null-findings for obtaining more accurate overall estimates of genetic effects.

Keywords: Catechol-O-Methyltransferase Val158Met polymorphism; Electroencephalographic alpha peak frequency; Major depressive disorder.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antidepressive Agents / therapeutic use
Australia
Case-Control Studies
Catechol O-Methyltransferase / genetics*
Cohort Studies
Depression / drug therapy
Depression / genetics*
Electroencephalography / methods*
Gene Frequency
Genotype
Humans
Male
Methionine / genetics
Polymerase Chain Reaction
Polymorphism, Genetic*
Prefrontal Cortex / drug effects
Valine / genetics

Substances

Antidepressive Agents
Methionine
COMT protein, human
Catechol O-Methyltransferase
Valine