New 9, 19-cycloartane triterpenoid from the root of Cimicifuga foetida

Chin J Nat Med. 2014 Apr;12(4):294-6. doi: 10.1016/S1875-5364(14)60057-1.

Abstract

Aim: To study the 9, 19-cycloartane triterpenes from the roots of Cimicifuga foetida.

Method: Chromatographic separations by silica gel, C18 reversed phase silica gel, and high-performance liquid chromatography (HPLC) were used. All of the structures were elucidated on the basis of spectroscopic analysis and chemical methods.

Results: Five 9, 19-cycloartane triterpenes, (3β, 12β, 15α, 24R)-12, 2'-diacetoxy-24, 25-epoxy-15-hydroxy-16, 23-dione-3-O-α-L-arabinopyranoside (1), actein (2), 23-epi-26-deoxyactein (3), asiaticoside B (4), and 12β-hydroxycimigenol (5) were isolated from the roots of Cimicifuga foetida.

Conclusion: Compound 1 is a new triterpene with two acetoxy groups at C-2' and C-12.

Keywords: 9, 19-Cycloartane triterpene; Acetoxy groups; Cimifuga foetida; Ranuncluaceae.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cimicifuga / chemistry*
  • Drugs, Chinese Herbal / chemistry*
  • Drugs, Chinese Herbal / isolation & purification
  • Molecular Structure
  • Plant Roots / chemistry*
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification

Substances

  • Drugs, Chinese Herbal
  • Triterpenes
  • cycloartane