Role of hypothermic machine perfusion in liver transplantation

Transpl Int. 2015 Jun;28(6):677-89. doi: 10.1111/tri.12354. Epub 2014 Jun 30.

Abstract

Machine liver perfusion has significantly evolved during the last ten years to optimize extended criteria liver grafts and to address the worldwide organ shortage. This review gives an overview on available ex vivo and in vivo data on hypothermic machine liver perfusion. We discuss also possible protective pathways and show most recent clinical applications of hypothermic machine liver perfusion in human.

Keywords: hypothermic oxygenated machine perfusion; marginal livers; oxygen; protective mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cold Temperature
  • Humans
  • Liver / pathology
  • Liver / surgery
  • Liver Transplantation / instrumentation
  • Liver Transplantation / methods*
  • Mitochondria / pathology
  • Organ Preservation / instrumentation
  • Organ Preservation / methods*
  • Organ Preservation Solutions
  • Oxidative Stress
  • Oxygen / chemistry
  • Perfusion / instrumentation*
  • Perfusion / methods
  • Temperature
  • Time Factors
  • Tissue and Organ Procurement

Substances

  • Organ Preservation Solutions
  • Oxygen