Abstract
Quercetin, a natural protective bioflavonoid, possesses diverse pharmacologic effects, such as antioxidant, anti-inflammatory, anti-proliferative, and anti-angiogenic activities. Recently, quercetin's effect in cancer prevention and treatment was recognized. However, the poor water solubility and low-bioavailability of quercetin limit its clinical use in cancer therapy. Nanotechnology provides a method to create novel formulations for hydrophobic drug. Nanoparticles-delivered quercetin has attracted many attentions for its enhanced anticancer potential and promising clinical application. This review will discuss the application of nanotechnology in quercetin delivery for cancer therapy.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / administration & dosage*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Proliferation / drug effects
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Drug Carriers / chemistry*
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Humans
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Nanoparticles / chemistry*
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Nanotechnology
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Neoplasms / drug therapy*
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Neoplasms / metabolism
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Neoplasms / pathology
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Quercetin / administration & dosage*
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Quercetin / chemistry
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Quercetin / isolation & purification
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Quercetin / pharmacology*
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Signal Transduction / drug effects
Substances
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Antineoplastic Agents, Phytogenic
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Drug Carriers
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Quercetin