Iron ERRs with Salmonella

Cell Host Microbe. 2014 May 14;15(5):515-6. doi: 10.1016/j.chom.2014.04.012.

Abstract

The hormone hepcidin promotes iron sequestration by macrophages. A recent study by Kim et al. (2014) implicates the orphan receptor ERRγ (estrogen-related receptor γ) in the regulation of hepcidin production and suggests that targeting the ERRγ-hepcidin axis may be beneficial during infection with the facultative intracellular pathogen Salmonella.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Hepatocytes / metabolism*
  • Hepcidins / metabolism*
  • Interleukin-6 / immunology*
  • Iron / metabolism*
  • Macrophages / metabolism*
  • Receptors, Estrogen / metabolism*
  • Salmonella Infections / metabolism*
  • Salmonella typhimurium*
  • Signal Transduction / immunology*

Substances

  • Hepcidins
  • Interleukin-6
  • Receptors, Estrogen
  • Iron