Coagulation profile in patients with H1N1 influenza A infection undergoing treatment for haematological malignancies

Blood Coagul Fibrinolysis. 2014 Dec;25(8):912-5. doi: 10.1097/MBC.0000000000000139.

Abstract

Patients with haematological malignancies receiving concurrent treatment or after allogeneic stem cell transplantation (HSCT) are considered to be at increased risk for acquiring influenza A (H1N1) infection (pH1N1) and influenza-associated complications leading to increased mortality. We report of a series of haematological patients with severe course of laboratory-confirmed pH1N1, including two patients after HSCT. Coagulation assays were conducted and the association between coagulation activation and poor outcome pH1N1 infection was found in the analyzed group.

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents / therapeutic use
  • Biomarkers / blood
  • Blood Coagulation Tests
  • Blood Coagulation*
  • Female
  • Hematologic Neoplasms / blood*
  • Hematologic Neoplasms / complications
  • Hematologic Neoplasms / mortality
  • Hematologic Neoplasms / therapy
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Influenza A Virus, H1N1 Subtype / physiology
  • Influenza, Human / blood*
  • Influenza, Human / complications
  • Influenza, Human / mortality
  • Influenza, Human / therapy
  • Male
  • Middle Aged
  • Prognosis
  • Survival Analysis
  • Transplantation, Homologous

Substances

  • Antineoplastic Agents
  • Biomarkers