[Evaluation of the linearity of pharmacokinetics of the phenolic antioxidant 4-methyl-2,6-diisobornylphenol upon intragastric administration]

V I Smol'iakova; G A Chernysheva; E A Ianovskaia; R V Gurto; A V Kuchin; I Iu Chukicheva; V V Udut; M B Plotnikov

[Evaluation of the linearity of pharmacokinetics of the phenolic antioxidant 4-methyl-2,6-diisobornylphenol upon intragastric administration]

Eksp Klin Farmakol. 2014;77(2):31-4.

[Article in Russian]

Authors

V I Smol'iakova, G A Chernysheva, E A Ianovskaia, R V Gurto, A V Kuchin, I Iu Chukicheva, V V Udut, M B Plotnikov

PMID: 24791338

Abstract

The linearity of pharmacokinetics of 4-methyl-2,6-diisobornylphenol after single intragastric administration in doses within 10 - 200 mg/kg has been studied in rats. It has been established that pharmacokinetics of 4-methyl-2,6-diisobornilphenol in the indicated dose range is not linear due to a limited absorption of the drug from the intestine.

MeSH terms

Animals
Antioxidants / administration & dosage
Antioxidants / metabolism
Antioxidants / pharmacokinetics*
Area Under Curve
Camphanes / administration & dosage
Camphanes / blood
Camphanes / pharmacokinetics*
Cresols / administration & dosage
Cresols / blood
Cresols / pharmacokinetics*
Drug Administration Schedule
Intestinal Absorption / physiology
Intestinal Mucosa / metabolism*
Male
Rats
Rats, Wistar
Stomach

Substances

4-methyl-2,6-diisobornylphenol
Antioxidants
Camphanes
Cresols