[A case of refractory testicular cancer showing complete response to high-dose chemotherapy with autologous bone marrow transplantation]

Gan To Kagaku Ryoho. 1989 Oct;16(10):3483-6.
[Article in Japanese]

Abstract

A patient with stage III testicular cancer was treated by 3 courses of BEP therapy and a partial response was obtained. Afterwards he underwent resection of pulmonary residual tumors and was treated by 2 courses of PE therapy immediately after operation. However, a new pulmonary tumor appeared after the first course of PE therapy was completed. He was treated by high-dose chemotherapy (etoposide 1200 mg/m2, cyclophosphamide 120 mg/kg, CDDP 60 mg/m2) with autologous bone marrow transplantation. Three weeks after high-dose chemotherapy his metastatic pulmonary tumor showed cavity formation which disappeared after 3 months. Fifteen months after the high-dose chemotherapy, no evidence of disease has been seen even without maintenance therapy.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Bleomycin / administration & dosage
  • Bone Marrow Transplantation*
  • Cisplatin / administration & dosage
  • Combined Modality Therapy
  • Cyclophosphamide / administration & dosage
  • Drug Resistance
  • Etoposide / administration & dosage
  • Humans
  • Male
  • Remission Induction
  • Teratoma / drug therapy*
  • Teratoma / surgery
  • Testicular Neoplasms / drug therapy*
  • Testicular Neoplasms / surgery
  • Transplantation, Autologous

Substances

  • Bleomycin
  • Etoposide
  • Cyclophosphamide
  • Cisplatin

Supplementary concepts

  • BEP protocol