Electrospinning of polymeric nanofibers for drug delivery applications

Xiuli Hu; Shi Liu; Guangyuan Zhou; Yubin Huang; Zhigang Xie; Xiabin Jing

doi:10.1016/j.jconrel.2014.04.018

Electrospinning of polymeric nanofibers for drug delivery applications

J Control Release. 2014 Jul 10:185:12-21. doi: 10.1016/j.jconrel.2014.04.018. Epub 2014 Apr 22.

Authors

Xiuli Hu¹, Shi Liu², Guangyuan Zhou³, Yubin Huang⁴, Zhigang Xie⁵, Xiabin Jing¹

Affiliations

¹ State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
² State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; The University of Chinese Academy of Sciences, Beijing 100049, PR China.
³ Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
⁴ State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China. Electronic address: ybhuang@ciac.ac.cn.
⁵ State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China. Electronic address: xiez@ciac.ac.cn.

PMID: 24768792
DOI: 10.1016/j.jconrel.2014.04.018

Abstract

Electrospinning has been recognized as a simple and versatile method for fabrication of polymer nanofibers. Various polymers that include synthetic, natural, and hybrid materials have been successfully electrospun into ultrafine fibers. The inherently high surface to volume ratio of electrospun fibers can enhance cell attachment, drug loading, and mass transfer properties. Drugs ranging from antibiotics and anticancer agents to proteins, DNA, RNA, living cells, and various growth factors have been incorporated into electrospun fibers. This article presents an overview of electrospinning techniques and their application in drug delivery.

Keywords: Drug delivery; Electrospinning; Local chemotherapy; Wound dressing.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Bandages
Drug Delivery Systems / instrumentation
Drug Delivery Systems / methods*
Electrochemical Techniques / instrumentation
Electrochemical Techniques / methods*
Equipment Design
Humans
Nanofibers / chemistry*
Nanofibers / ultrastructure
Pharmaceutical Preparations / administration & dosage*
Polymers / chemistry

Substances

Pharmaceutical Preparations
Polymers