A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas

EMBO J. 1989 May;8(5):1403-10. doi: 10.1002/j.1460-2075.1989.tb03521.x.

Abstract

B cells and primary carcinomas express a surface molecule, Bp50 (CDw40), absent from other hematopoietic cells and from normal epithelium, and thought to play a regulatory role in B-cell maturation and epithelial neoplasia. In this work the sequence of a cDNA clone encoding Bp50 was analyzed by a newly derived transition matrix method. Among several interesting relationships with known receptors was found an extensive homology with the nerve growth factor receptor. The mRNA is induced by gamma-interferon in both B cells and epithelial neoplasms, suggesting a role for the molecule in the development of carcinomas at sites of chronic inflammation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Antigens, Differentiation, B-Lymphocyte / genetics*
  • B-Lymphocytes / immunology*
  • Base Sequence
  • Biological Factors / pharmacology
  • CD40 Antigens
  • Carcinoma / genetics
  • Carcinoma / immunology
  • Carcinoma / metabolism
  • Cytokines
  • Gene Expression Regulation
  • HLA-DR Antigens / genetics
  • Humans
  • Lymphocyte Activation
  • Molecular Sequence Data
  • Mutation
  • Nerve Growth Factors / metabolism*
  • Receptors, Cell Surface / genetics*
  • Receptors, Nerve Growth Factor
  • Sequence Homology, Nucleic Acid

Substances

  • Antigens, Differentiation, B-Lymphocyte
  • Biological Factors
  • CD40 Antigens
  • Cytokines
  • HLA-DR Antigens
  • Nerve Growth Factors
  • Receptors, Cell Surface
  • Receptors, Nerve Growth Factor