Next-generation sequencing of urologic cancers: next is now

Francisco X Real; Paul C Boutros; Núria Malats

doi:10.1016/j.eururo.2014.03.028

Next-generation sequencing of urologic cancers: next is now

Eur Urol. 2014 Jul;66(1):4-7. doi: 10.1016/j.eururo.2014.03.028. Epub 2014 Apr 5.

Authors

Francisco X Real¹, Paul C Boutros², Núria Malats³

Affiliations

¹ Epithelial Carcinogenesis Group, CNIO-Spanish National Cancer Research Center, Madrid, Spain; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain. Electronic address: preal@cnio.es.
² Ontario Institute for Cancer Research, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada.
³ Genetic and Molecular Epidemiology Group, CNIO-Spanish National Cancer Research Center, Madrid, Spain.

PMID: 24731787
DOI: 10.1016/j.eururo.2014.03.028

Abstract

The exomes/genomes of a few hundred kidney, bladder, and prostate tumours have been sequenced. This sequencing has unveiled new genes that are altered and new opportunities for tumour subclassification, prediction of outcome, and therapy. These opportunities will soon become realities.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Renal Cell / genetics*
DNA Mutational Analysis / methods*
DNA, Neoplasm / analysis*
Humans
Kidney Neoplasms / genetics*
Male
Prostatic Neoplasms / genetics*
Urinary Bladder Neoplasms / genetics*

Substances

DNA, Neoplasm

Grants and funding

R01-CA089715/CA/NCI NIH HHS/United States