A bubble-mediated intelligent microscale electrochemical device for single-step quantitative bioassays

Fan Yang; Xiaolei Zuo; Zhenhua Li; Wangping Deng; Jiye Shi; Guojun Zhang; Qing Huang; Shiping Song; Chunhai Fan

doi:10.1002/adma.201400451

A bubble-mediated intelligent microscale electrochemical device for single-step quantitative bioassays

Adv Mater. 2014 Jul 16;26(27):4671-6. doi: 10.1002/adma.201400451. Epub 2014 Apr 14.

Authors

Fan Yang¹, Xiaolei Zuo, Zhenhua Li, Wangping Deng, Jiye Shi, Guojun Zhang, Qing Huang, Shiping Song, Chunhai Fan

Affiliation

¹ Division of Physical, Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Microscale Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China; School of Laboratory Medicine, Hubei University of Chinese Medicine, 1 Huangjia Lake West Road, Wuhan, China.

PMID: 24729272
DOI: 10.1002/adma.201400451

Abstract

An intelligent microscale electrochemical device (iMED) for one-step, quantitative and multiplexed electrochemical detection of biomarkers for infectious diseases and tumors is developed. A "plug-in-cartridge" technology is introduced and adapted for use in screen-printed electrodes (SPEs) in electrochemical devices. Using this iMED, biomarkers for two types of tumors and one infectious disease are detected at sub-ng/mL levels in less than 30 min.

Keywords: bioassays; electrochemistry; electrodes; microfluidics; proteins.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biological Assay / instrumentation*
Dimethylpolysiloxanes / chemistry
Electrochemistry / instrumentation*
Humans
Influenza A Virus, H1N1 Subtype / immunology
Influenza Vaccines / analysis
Microtechnology / instrumentation*
Prostate-Specific Antigen / blood

Substances

Dimethylpolysiloxanes
Influenza Vaccines
baysilon
Prostate-Specific Antigen