Malignant germ cell sacrococcygeal tumors in children. Improved prognosis after introduction of cisplatin-containing multiple drug treatment

Acta Oncol. 1989;28(2):249-51. doi: 10.3109/02841868909111257.

Abstract

The survival of children with malignant germ cell sacrococcygeal tumors has improved during the last few years after introduction of a multidrug protocol including cisplatinum. Treatment for 10 patients registered in 1965-1978 was not uniform and consisted of surgical resection or biopsy and radiotherapy with or without multiple drug chemotherapy (methotrexate + actinomycin D + cyclophosphamide). Only one of these patients is alive. Fifteen patients registered between 1978 and 1986 were treated with actinomycin D + cyclophosphamide + vincristine + doxorubicin + bleomycin + cisplatinum. Four patients also received radiotherapy. Seven out of these 15 children are alive without evidence of disease.

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Bleomycin / administration & dosage
  • Child
  • Child, Preschool
  • Cisplatin / administration & dosage
  • Cyclophosphamide / administration & dosage
  • Dactinomycin / administration & dosage
  • Doxorubicin / administration & dosage
  • Dysgerminoma / drug therapy*
  • Female
  • Humans
  • Infant
  • Male
  • Prognosis
  • Sacrococcygeal Region*
  • Teratoma / drug therapy*
  • Vincristine / administration & dosage

Substances

  • Bleomycin
  • Dactinomycin
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Cisplatin