Abstract
Chronic kidney disease is one of the major health problems worldwide. DNA vaccination delivers plasmid DNA encoding the target gene to induce both humoral and cellular immune responses. Here, we describe the methods of CD40 DNA vaccine enhanced by dendritic cell (DC) targeting on the development of Heymann nephritis (HN), a rat model of human membranous nephropathy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens / immunology
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Disease Models, Animal
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Humans
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Kidney Tubules / immunology
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Male
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Rats
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Renal Insufficiency, Chronic / immunology*
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Renal Insufficiency, Chronic / pathology
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Renal Insufficiency, Chronic / physiopathology
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Renal Insufficiency, Chronic / therapy*
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Vaccination*
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Vaccines, DNA / administration & dosage
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Vaccines, DNA / immunology*