High density of CD68+/CD163+ tumour-associated macrophages (M2-TAM) at diagnosis is significantly correlated to unfavorable prognostic factors and to poor clinical outcomes in patients with diffuse large B-cell lymphoma

Hematol Oncol. 2015 Jun;33(2):110-2. doi: 10.1002/hon.2142. Epub 2014 Apr 8.

Affiliations

¹ Hematology Unit, Campus Bio-Medico University Hospital, Rome, Italy.
² Pathology Unit, Campus Bio-Medico University Hospital, Rome, Italy.
³ IRCCS G.B. Bietti Foundation, Rome, Italy.
⁴ Ophthalmology Unit, Campus Bio-Medico University Hospital, Rome, Italy.

PMID: 24711044
DOI: 10.1002/hon.2142

No abstract available

Publication types

Letter

MeSH terms

Antibodies, Monoclonal, Murine-Derived / administration & dosage
Antigens, CD / analysis*
Antigens, Differentiation, Myelomonocytic / analysis*
Antineoplastic Combined Chemotherapy Protocols / administration & dosage
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Cell Count
Cyclophosphamide / administration & dosage
Disease-Free Survival
Doxorubicin / administration & dosage
Doxorubicin / analogs & derivatives
Humans
Immunophenotyping
Kaplan-Meier Estimate
Lymphoma, Large B-Cell, Diffuse / drug therapy
Lymphoma, Large B-Cell, Diffuse / immunology
Lymphoma, Large B-Cell, Diffuse / mortality
Lymphoma, Large B-Cell, Diffuse / pathology*
Macrophages / chemistry
Macrophages / pathology*
Polyethylene Glycols / administration & dosage
Prednisone / administration & dosage
Prognosis
Receptors, Cell Surface / analysis*
Rituximab
Treatment Outcome
Vincristine / administration & dosage

Substances

Antibodies, Monoclonal, Murine-Derived
Antigens, CD
Antigens, Differentiation, Myelomonocytic
CD163 antigen
CD68 antigen, human
Receptors, Cell Surface
liposomal doxorubicin
Polyethylene Glycols
Rituximab
Vincristine
Doxorubicin
Cyclophosphamide
Prednisone

Supplementary concepts

CHOP protocol