Association of human papilloma virus with atypical and malignant oral papillary lesions

Christina McCord; Jing Xu; Wei Xu; Xin Qiu; Nidal Muhanna; Jonathan Irish; Iona Leong; Richard John McComb; Bayardo Perez-Ordonez; Grace Bradley

doi:10.1016/j.oooo.2014.02.003

Association of human papilloma virus with atypical and malignant oral papillary lesions

Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Jun;117(6):722-32. doi: 10.1016/j.oooo.2014.02.003. Epub 2014 Feb 14.

Authors

Christina McCord¹, Jing Xu², Wei Xu³, Xin Qiu³, Nidal Muhanna⁴, Jonathan Irish⁴, Iona Leong⁵, Richard John McComb⁶, Bayardo Perez-Ordonez⁷, Grace Bradley⁸

Affiliations

¹ Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada. Electronic address: Christina.mccord@utoronto.ca.
² Applied Molecular Profiling Laboratory, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada.
³ Department of Biostatistics, University Health Network, Toronto, Ontario, Canada.
⁴ Department of Surgical Oncology/Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
⁵ Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada; Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.
⁶ Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.
⁷ Department of Pathology, University Health Network, Toronto, Ontario, Canada.
⁸ Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada; Ontario Cancer Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.

PMID: 24703405
DOI: 10.1016/j.oooo.2014.02.003

Abstract

Objective: This study aimed to examine atypical and malignant papillary oral lesions for low- and high-risk human papillomavirus (HPV) infection and to correlate HPV infection with clinical and pathologic features.

Study design: Sections of 28 atypical papillary lesions (APLs) and 14 malignant papillary lesions (MPLs) were examined for HPV by in situ hybridization and for p16 and MIB-1 by immunohistochemistry; 24 conventional papillomas were studied for comparison.

Results: Low-risk HPV was found in 10 of 66 cases, including 9 APLs and 1 papilloma. All low-risk HPV-positive cases showed suprabasilar MIB-1 staining, and the agreement was statistically significant (P < .0001). Diffuse p16 staining combined with high-risk HPV was not seen in any of the cases. A subset of HPV(-) APLs progressed to carcinoma.

Conclusions: Oral papillary lesions are a heterogeneous group. Low-risk HPV infection is associated with a subset of APLs with a benign clinical course. Potentially malignant APLs and MPLs are not associated with low- or high-risk HPV.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Antibodies, Antinuclear / pharmacology
Antibodies, Monoclonal / pharmacology
Biomarkers, Tumor / metabolism
Biopsy
DNA, Viral / metabolism
Female
Humans
Immunohistochemistry
In Situ Hybridization
Ki-67 Antigen / metabolism
Male
Middle Aged
Mouth Neoplasms / virology*
Papilloma / virology*
Precancerous Conditions / virology
Retrospective Studies
Risk Factors

Substances

Antibodies, Antinuclear
Antibodies, Monoclonal
Biomarkers, Tumor
DNA, Viral
Ki-67 Antigen
MIB-1 antibody