Methods-based proficiency testing in molecular genetic pathology

Iris Schrijver; Nazneen Aziz; Lawrence J Jennings; Carolyn Sue Richards; Karl V Voelkerding; Karen E Weck

doi:10.1016/j.jmoldx.2014.02.002

Methods-based proficiency testing in molecular genetic pathology

J Mol Diagn. 2014 May;16(3):283-7. doi: 10.1016/j.jmoldx.2014.02.002. Epub 2014 Mar 18.

Authors

Iris Schrijver¹, Nazneen Aziz², Lawrence J Jennings³, Carolyn Sue Richards⁴, Karl V Voelkerding⁵, Karen E Weck⁶

Affiliations

¹ Department of Pathology, Stanford University Medical Center, Stanford, California; Department of Pediatrics, Stanford University Medical Center, Stanford, California. Electronic address: ischrijver@stanfordmed.org.
² Transformation Program Office, College of American Pathologists, Northfield, Illinois.
³ Department of Pathology and Laboratory Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois; Department of Pathology and Laboratory Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
⁴ Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon.
⁵ Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah; ARUP Laboratories Institute for Clinical and Experimental Pathology, Salt Lake City, Utah.
⁶ Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina.

PMID: 24650895
DOI: 10.1016/j.jmoldx.2014.02.002

Abstract

This Perspectives article describes methods-based proficiency testing (MBPT), the benefits and limitations of MBPT, why the time is right for MBPT in molecular diagnostics, and how MBPT for next-generation sequencing is being developed by the College of American Pathologists.

MeSH terms

Clinical Laboratory Services* / standards
Gene Library
Genetic Testing / methods*
Genetic Testing / standards
Humans
Laboratory Proficiency Testing / methods*
Laboratory Proficiency Testing / standards
Sequence Analysis / methods
Sequence Analysis / standards
Validation Studies as Topic
Workflow