Mutations located on both F1 and F2 subunits of the Newcastle disease virus fusion protein confer resistance to neutralization with monoclonal antibodies

C Neyt; J Geliebter; M Slaoui; D Morales; G Meulemans; A Burny

doi:10.1128/JVI.63.2.952-954.1989

Mutations located on both F1 and F2 subunits of the Newcastle disease virus fusion protein confer resistance to neutralization with monoclonal antibodies

J Virol. 1989 Feb;63(2):952-4. doi: 10.1128/JVI.63.2.952-954.1989.

Authors

C Neyt¹, J Geliebter, M Slaoui, D Morales, G Meulemans, A Burny

Affiliation

¹ Laboratory of Biological Chemistry, Free University of Brussels, Belgium.

Abstract

The fusion gene sequence of six Newcastle disease virus escape mutants revealed that residues important for the integrity of antigenic site 1 and antigenic site 2 were located, respectively, on the F2 subunit and within the cysteine-rich domain of the F1 subunit. We further report the antibody-binding capacity of these mutants.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Antibodies, Monoclonal / immunology
Antibodies, Viral / immunology
Antigens, Viral / genetics*
Antigens, Viral / immunology
Epitopes / genetics
Molecular Sequence Data
Neutralization Tests
Newcastle disease virus / genetics*
Newcastle disease virus / immunology
Protein Binding
Viral Fusion Proteins / genetics*
Viral Fusion Proteins / immunology

Substances

Antibodies, Monoclonal
Antibodies, Viral
Antigens, Viral
Epitopes
Viral Fusion Proteins