Ethanolic carbon-11 chemistry: the introduction of green radiochemistry

Xia Shao; Maria V Fawaz; Keunsam Jang; Peter J H Scott

doi:10.1016/j.apradiso.2014.01.033

Ethanolic carbon-11 chemistry: the introduction of green radiochemistry

Appl Radiat Isot. 2014 Jul:89:125-9. doi: 10.1016/j.apradiso.2014.01.033. Epub 2014 Feb 15.

Authors

Xia Shao¹, Maria V Fawaz¹, Keunsam Jang¹, Peter J H Scott²

Affiliations

¹ Division of Nuclear Medicine, Department of Radiology, The University of Michigan Medical School, Ann Arbor, MI, USA.
² Division of Nuclear Medicine, Department of Radiology, The University of Michigan Medical School, Ann Arbor, MI, USA; The Interdepartmental Program in Medicinal Chemistry, The University of Michigan, Ann Arbor, MI, USA. Electronic address: pjhscott@umich.edu.

Abstract

The principles of green chemistry have been applied to a radiochemistry setting. Eleven carbon-11 labeled radiopharmaceuticals have been prepared using ethanol as the only organic solvent throughout the entire manufacturing process. The removal of all other organic solvents from the process simplifies production and quality control (QC) testing, moving our PET Center towards the first example of a green radiochemistry laboratory. All radiopharmaceutical doses prepared are suitable for clinical use.

Keywords: Carbon-11; Green chemistry; PET chemistry; Positron emission tomography; Radiopharmaceutical synthesis.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Carbon Radioisotopes / chemistry*
Ethanol / chemistry*
Green Chemistry Technology / methods
Isotope Labeling / methods
Radiochemistry / methods
Radiopharmaceuticals / chemical synthesis*
Radiopharmaceuticals / chemistry

Substances

Carbon Radioisotopes
Radiopharmaceuticals
Ethanol

Abstract

Publication types

MeSH terms

Substances

Grants and funding