Neutrophils cast NETs in atherosclerosis: employing peptidylarginine deiminase as a therapeutic target

Circ Res. 2014 Mar 14;114(6):931-4. doi: 10.1161/CIRCRESAHA.114.303479.

Authors

Yvonne Döring¹, Oliver Soehnlein, Christian Weber

Affiliation

¹ From Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Germany (Y.D., O.S., C.W.); Academic Medical Center, Department of Pathology, Amsterdam University, the Netherlands (O.S.); and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Germany (O.S., C.W.).

PMID: 24625721
DOI: 10.1161/CIRCRESAHA.114.303479

No abstract available

Keywords: N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide; atherosclerosis; protein-arginine deiminase.

Publication types

Editorial
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Atherosclerosis / prevention & control*
Enzyme Inhibitors / therapeutic use*
Hydrolases / antagonists & inhibitors*
Immunity, Innate / drug effects*
Ornithine / analogs & derivatives*
Ornithine / therapeutic use
Protein-Arginine Deiminase Type 4

Substances

Enzyme Inhibitors
N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide
Ornithine
Hydrolases
Protein-Arginine Deiminase Type 4
peptidylarginine deiminase 4, mouse