Potassium channels expressed from rat brain cDNA have delayed rectifier properties

FEBS Lett. 1988 Dec 19;242(1):199-206. doi: 10.1016/0014-5793(88)81015-9.

Abstract

Injection into Xenopus oocytes of RNA synthesized in vitro using the rat brain cDNA RCK1 as a template or nuclear injection of the cDNA results in the expression of functional potassium channels. These channels exhibit properties similar to those of the non-inactivating delayed rectifier channel found in mammalian neurons and other excitable cells.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Aminopyridine
  • Aminopyridines / pharmacology
  • Animals
  • Cell Membrane / metabolism
  • Cerebral Cortex / analysis*
  • DNA / genetics*
  • Elapid Venoms / pharmacology
  • Electric Conductivity
  • Female
  • Gene Expression Regulation
  • Histamine Release / drug effects
  • Membrane Potentials
  • Oocytes / metabolism*
  • Peptides / pharmacology
  • Potassium / pharmacology
  • Potassium Channels / drug effects
  • Potassium Channels / physiology*
  • Rats
  • Tetraethylammonium
  • Tetraethylammonium Compounds / pharmacology
  • Xenopus

Substances

  • Aminopyridines
  • Elapid Venoms
  • Peptides
  • Potassium Channels
  • Tetraethylammonium Compounds
  • mast cell degranulating peptide
  • Tetraethylammonium
  • dendrotoxin
  • DNA
  • 4-Aminopyridine
  • Potassium