Abstract
We report a 58-year-old Japanese man with acute lymphoblastic leukemia. On the seventh day of his second course of consolidation therapy, he developed herpes zoster, and on the 17th day, he developed a high fever, dyspnea, and lapsed into a coma. Streptococcus constellatus was isolated from blood culture. Despite intensive therapy, multiple organ failure progressed rapidly, and he died on the 19th day. Pathological examination of autopsy specimens revealed bone marrow necrosis and fat embolism in multiple organs. In this patient, sepsis led to bone marrow necrosis and, subsequently, to fat embolism.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Bone Marrow / pathology*
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Consolidation Chemotherapy / adverse effects*
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Cyclophosphamide / administration & dosage
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Cyclophosphamide / adverse effects
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Dexamethasone / administration & dosage
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Dexamethasone / adverse effects
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Doxorubicin / administration & dosage
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Doxorubicin / adverse effects
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Embolism, Fat / etiology*
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Fatal Outcome
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Herpes Zoster / etiology
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Humans
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Induction Chemotherapy
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Male
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Middle Aged
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Multiple Organ Failure / etiology
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Necrosis / etiology
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
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Sepsis / etiology*
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Streptococcal Infections / etiology*
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Streptococcus constellatus*
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Vincristine / administration & dosage
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Vincristine / adverse effects
Substances
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Vincristine
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Dexamethasone
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Doxorubicin
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Cyclophosphamide