Abstract
Two new anthraquinone dimers, melrubiellin A (1) and melrubiellin B (2), were isolated from the aerial part of Melandrium firmum Rohrbach, along with seven known compounds (3-9). The structures of these compounds were elucidated by spectral analyses, including 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) experiments. Compound 1 and 2 exhibited significant cytotoxicity towards HeLa, NCI-H460, Hep G2, Hep 3B and MKN-28 cell lines with IC50 values ranging from 5.26 to 81.16 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anthraquinones / isolation & purification*
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Anthraquinones / pharmacology*
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Line, Tumor
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Cell Survival / drug effects
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Drug Screening Assays, Antitumor
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HeLa Cells
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Hep G2 Cells
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Humans
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Plant Extracts / chemistry
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Silene / chemistry*
Substances
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Anthraquinones
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Antineoplastic Agents, Phytogenic
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Plant Extracts
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melrubiellin A
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melrubiellin B