[Molecular profiling of non-small cell lung cancer]

L Gibault; A Cazes; C Narjoz; H Blons

doi:10.1016/j.pneumo.2013.11.005

[Molecular profiling of non-small cell lung cancer]

Rev Pneumol Clin. 2014 Feb-Apr;70(1-2):47-62. doi: 10.1016/j.pneumo.2013.11.005. Epub 2014 Feb 22.

[Article in French]

Authors

L Gibault¹, A Cazes², C Narjoz³, H Blons⁴

Affiliations

¹ Service de pathologie, hôpital européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75015 Paris, France.
² Service de pathologie, hôpital européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75015 Paris, France; Université Paris Descartes, 12, rue de l'École-de-Médecine, 75006 Paris, France.
³ Service de biochimie, UF de pharmacogénétique et oncologie moléculaire, hôpital européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75015 Paris, France.
⁴ Université Paris Descartes, 12, rue de l'École-de-Médecine, 75006 Paris, France; Service de biochimie, UF de pharmacogénétique et oncologie moléculaire, hôpital européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75015 Paris, France; UMR-S775, Inserm, centre universitaire des Saints-Pères, 46, rue des Saints-Pères, 75006 Paris, France. Electronic address: helene.blons@egp.aphp.fr.

PMID: 24566035
DOI: 10.1016/j.pneumo.2013.11.005

Abstract

The management of locally advanced and metastatic non-small cell lung cancer has been revolutionized thanks to recent progress in pathology and molecular biology. The first molecular subgroup is defined by activating mutations of the epidermal growth factor receptor (EGFR), and a dramatic response to specific tyrosine kinase inhibitors. Since then, multiple genetic alterations (KRAS, HER2, BRAF, PIK3CA, ALK, ROS, RET…) have been identified as potential target of novel therapies, and molecular profiling has become common practice. This review focus on the molecular alterations associated with non-small cell lung cancer, including molecular profiling and response to targeted therapies.

Keywords: Adénocarcinomes du poumon; Biologie moléculaire; Molecular biology; Non-small cell lung cancer.

Publication types

English Abstract
Review

MeSH terms

Carcinoma, Non-Small-Cell Lung / drug therapy
Carcinoma, Non-Small-Cell Lung / genetics*
Decision Trees
Gene Expression Profiling
Humans
Lung Neoplasms / drug therapy
Lung Neoplasms / genetics*
Molecular Targeted Therapy
Mutation