Particle replication in nonwetting templates nanoparticles with tumor selective alkyl silyl ether docetaxel prodrug reduces toxicity

Nano Lett. 2014 Mar 12;14(3):1472-6. doi: 10.1021/nl4046558. Epub 2014 Feb 24.

Abstract

Delivery systems designed to have triggered release after passively targeting the tumor may improve small molecule chemotherapeutic delivery. Particle replication in nonwetting templates was used to prepare nanoparticles to passively target solid tumors in an A549 subcutaneous xenograft model. An acid labile prodrug was delivered to minimize systemic free docetaxel concentrations and improve tolerability without compromising efficacy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Docetaxel
  • Drug Carriers* / chemistry
  • Drug Carriers* / pharmacology
  • Humans
  • Mice
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Prodrugs* / chemistry
  • Prodrugs* / pharmacology
  • Taxoids* / chemistry
  • Taxoids* / pharmacology
  • Wettability
  • Xenograft Model Antitumor Assays

Substances

  • Drug Carriers
  • Prodrugs
  • Taxoids
  • Docetaxel