Developmentally regulated alternative splicing of brain myelin-associated glycoprotein mRNA is lacking in the quaking mouse

FEBS Lett. 1988 May 23;232(2):323-7. doi: 10.1016/0014-5793(88)80762-2.

Abstract

Evidence is presented that expression of the two myelin-associated glycoprotein mRNAs is developmentally regulated in mouse brain. In quaking mouse, the mRNA without a 45-nucleotide exon portion was scarcely expressed throughout development. We conclude that the mechanism of splicing out the 45-nucleotide exon portion is lacking in quaking mouse.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Brain / growth & development*
  • Brain / metabolism
  • DNA / genetics
  • Demyelinating Diseases / genetics
  • Exons
  • Mice
  • Mice, Quaking
  • Molecular Sequence Data
  • Myelin Proteins / genetics*
  • Myelin-Associated Glycoprotein
  • Nucleic Acid Hybridization
  • RNA Splicing*
  • RNA, Messenger / genetics*

Substances

  • Myelin Proteins
  • Myelin-Associated Glycoprotein
  • RNA, Messenger
  • DNA

Associated data

  • GENBANK/X07849